Which melatonin? 3 mg vs 20 mg vs 150 mg

by Stephanie Grutz, ARNP, FNP-C on Nov 13 2026
In this article

    We carry three melatonins, and they are not interchangeable. Dose determines what melatonin does.

    Read the video transcript

    Which melatonin? What's the difference between Select Balance's three melatonins? Melatonin, the three milligram lozenge, is a gentle one for your sleep-wake rhythm. Melatonin Plus is 20 milligrams for when your practitioner has asked you to take higher doses at bedtime. Melatonin high dose, one hundred and fifty milligrams, is a different product altogether.

    It's practitioner-directed and used under medical supervision as part of a care plan. It is not a sleep aid. All three are made in the USA in a GMP-certified facility. If you're asking about the hundred and fifty milligram, tap the Ask Steph, and my team and I will help you directly.

    Melatonin 3 mg lozenge

    A gentle one for your sleep-wake rhythm. In the 0.3 to 5 mg range, melatonin matches what your pineal gland makes and works through your sleep receptors. Low-dose melatonin isn't sedating... it's synchronizing. Good for occasional sleeplessness, travel across time zones and shifting work schedules.

    Melatonin Plus, 20 mg

    For when your practitioner has asked you to take higher doses at bedtime. In the 10 to 60 mg range, the sleep receptors are saturated, so the extra melatonin works through antioxidant and mitochondrial pathways, supporting a healthy inflammatory response, the gut lining and balanced immune function. It's not recommended for anyone under 18, and check with your practitioner if you take blood thinners, sedatives, blood pressure medication or immunotherapy.

    Melatonin High Dose, 150 mg

    A different product altogether. It's practitioner-directed and used under medical supervision as part of a care plan. It is not a sleep aid. I formulated it in 2021 as the first high-dose, over-the-counter 150 mg melatonin capsule in the USA. If you're asking about the 150 mg, tap Ask Steph, and my team and I will help you directly.

    All three are made in the USA in a GMP-certified facility and third-party tested. See them side by side in our Sleep Support collection.

    Stephanie Grutz, ARNP, FNP-C, is an integrative board-certified family nurse practitioner and the founder of Select Balance. This article is general education, not medical advice. Talk with your own provider about your situation.